Prasterone acetate and Hydrocortisone steroid intermediates

Hydrocortisone and Prasterone acetate steroid intermediates from Pfizer CentreOne are found in therapeutics treating millions of patients every day.

Reliable commercial supply

Manufactured in the U.S., Pfizer CentreOne has been reliably synthesizing and supplying commercial volumes of Hydrocortisone and Prasterone acetate steroid intermediates to leading pharma and fine chemical companies for decades.

For formulators and manufacturers completing synthesis using their own actives, Pfizer CentreOne also offers a wide range of currently marketed intermediates suitable for conversion into:

Betamethasones
Beclomethasones
Dexamethasones
Mometasones

Budesonides
Ciclesonides
Triamcinolone family
Prasterone derivatives

Most offered with complete US Drug Master files, ask your Pfizer CentreOne representative.

Pfizer CentreOne offers a full complement of intermediates from Pfizer’s industry-leading legacy of steroid innovation to help you accelerate development and boost therapeutic performance. Don’t see what you need? Contact us today and let our steroid intermediate experts custom synthesize the specific chemistry you need to make your product a commercial success.

Approved for medical use in 1941, hydrocortisone USP is used widely in topical treatments for inflammation and is on the World Health Organization's List of Essential Medicines. Prasterone, the most common steroid hormone found in humans, is a precursor for both androgens and oestrogens. Prasterone acetate, a key intermediate, is used in the commercial processing of select steroid based APIs.

Available formulations

Prasterone acetate
Hydrocortisone USP

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Pfizer CentreOne steroid intermediates, API
and related products

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Specifications

Chemical name Sort descending	CAS#	Compendial	Formula	Molar mass
Hydrocortisone USP	Cas # - 50-23-7	Compendial - USP, EP, Canada, IP, JP and more	Formula - C₂₁H₃₀O₅	Molar mass - 362.4 g/mol
Prasterone acetate	Cas # - 853-23-6	Compendial - US DMF	Formula - C₂₁H₃₀O₃	Molar mass - 330.4 g/mol

Why partner with Pfizer CentreOne for API supply?

Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.

We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.

Our track record is our strongest asset, and this means our customers can count on us for their critical API supply.

When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:

Reliable API supply at flexible commercial volumes
Industry-leading EHS and compliance track record
Advanced, efficient and environmentally friendly chemistries and processes
Regulatory support to enable your product’s success
Robust, low-risk internal supply chain from raw material to API
Transparent timelines and a responsive, dedicated customer support team
Drug product development and manufacturing services
Experienced teams backed by world-class Pfizer quality manufacturing systems – 25% of Kalamazoo colleagues are in dedicated quality roles
A track record you can trust

Related API products

Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.

Enviero Progesterone^* Heparin Hydrocortisone Progesterone Prostaglandins Steroid Intermediates Testosterone

* Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.

Let’s collaborate on your API today

To find out more about Pfizer CentreOne’s APIs and intermediates, as well commercial pricing and supply availability click here.

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