The first total syntheses of prostaglandin F2α was reported in 1969 and achieved the Japan Prize in 1989. Dinoprost, the name given to prostaglandin when used as a pharmaceutical, is used to support human and animal health. Epoprostenol sodium, a powerful vasodilator, is commonly used to treat pulmonary arterial hypertension.

Contact us for more information on Pfizer CentreOne Dinoprost tromethamine and Epoprostenol sodium Prostaglandin API and related products

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Specifications

Chemical name CAS# Compendial Formula Molar mass
Dinoprost tromethamine Cas # - 38562-01-5 Compendial - USP, EP
Formula -  

C20H33O5

Molar mass - 475.6 g/mol
Epoprostenol sodium Cas # - 61849-14-7 Compendial - USP, TGA, EU and more
Formula -  

C20H31NaO5

Molar mass - 374.4 g/mol

Why partner with Pfizer CentreOne for API supply? 

Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.

We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.

Our track record is our strongest asset, and this means our customers can count on us for their critical API supply. 

When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:

  • Reliable API supply at flexible commercial volumes
  • Industry-leading EHS and compliance track record
  • Advanced, efficient and environmentally friendly chemistries and processes
  • Regulatory support to enable your product’s success  
  • Robust, low-risk internal supply chain from raw material to API
  • Transparent timelines and a responsive, dedicated customer support team
  • Drug product development and manufacturing services
  • Experienced teams backed by world-class Pfizer quality manufacturing systems – 25% of Kalamazoo colleagues are in dedicated quality roles 
  • A track record you can trust 

Related API products

Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.

Dexamethasone
Enviero Progesterone*
Heparin 
Hydrocortisone
Progesterone 
Steroid Intermediates 
Testosterone

*Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.

Let’s collaborate on your API today

To find out more about Pfizer CentreOne’s API and intermediates, as well commercial pricing and supply availability click here.