Progesterone steroid hormones

Progesterone APIs from Pfizer CentreOne provide the foundation for a broad range of therapeutics related to women’s reproductive health.

Reliable commercial supply

Semi-synthesized from phytosterols, progesterone’s commercial API form is safely prescribed to women around the world every day. Manufactured in the U.S., Pfizer CentreOne has been reliably synthesizing and supplying commercial

First discovered in 1929 and approved in the 1930s via animal extracts, an economic and more efficient synthesis of progesterone from yams was commercialized in 1940. Subsequently, Pfizer’s legacy company Upjohn, revolutionized the manufacture using a derivative from abundant plant sterols, making Progesterone more broadly available. Progesterone is one of the most prescribed medications in the U.S., with more than 3 million prescriptions written in 2018¹.

¹https://clincalc.com/DrugStats/Drugs/Progesterone

A range of chemistries and
particle sizes

Progesterone steroids from Pfizer CentreOne are available in a range of particle sizes for a broad range of pharmaceutical applications:

Progesterone micronized for soft gel
Progesterone USP micronized
Progesterone USP
Progesterone USP wettable powder (Surfactant Free)

Let’s collaborate

Contact us for more information on
Pfizer CentreOne progesterone API
and related products

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Specifications

Chemical name Sort descending	CAS#	Compendial	Formula	Molar mass
Progesterone micronized for soft gel	Cas # - 57-83-0	Compendial - US, EP, Canada, IP and more	Formula - C₂₁H₃₀O₃	Molar mass - 314.4 g/mol
Progesterone USP	Cas # - 57-83-0	Compendial - US, EP, Canada, IP and more	Formula - C₂₁H₃₀O₃	Molar mass - 314.4 g/mol
Progesterone USP micronized	Cas # - 57-83-0	Compendial - US, EP, Canada, IP and more	Formula - C₂₁H₃₀O₃	Molar mass - 314.4 g/mol
Progesterone wettable powder	Cas # - 57-83-0	Compendial - USP, EP, Canada, IP, JP and more	Formula - C₂₁H₃₀O₃	Molar mass - 314.4 g/mol

Why partner with Pfizer CentreOne for API supply?

Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.

We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.

Our track record is our strongest asset, and this means our customers can count on us for their critical API supply.

When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:

Reliable API supply at flexible commercial volumes
Industry-leading EHS and compliance track record
Advanced, efficient and environmentally friendly chemistries and processes
Regulatory support to enable your product’s success
Robust, low-risk internal supply chain from raw material to API
Transparent timelines and a responsive, dedicated customer support team
Drug product development and manufacturing services
Experienced teams backed by world-class Pfizer quality manufacturing systems – 25% of Kalamazoo colleagues are in dedicated quality roles
A track record you can trust

Related API products

Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.

Enviero Progesterone^* Heparin Hydrocortisone Progesterone Prostaglandins Steroid Intermediates Testosterone

* Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.

Let’s collaborate on your API today

To find out more about Pfizer CentreOne’s APIs and intermediates, as well commercial pricing and supply availability click here.

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