First discovered in 1929 and approved in the 1930s via animal extracts, an economic and more efficient synthesis of progesterone from yams was commercialized in 1940.  Subsequently, Pfizer’s legacy company Upjohn, revolutionized the manufacture using a derivative from abundant plant sterols, making Progesterone more broadly available.  Progesterone is one of the most prescribed medications in the U.S., with more than 3 million prescriptions written in 20181.


A range of chemistries and particle sizes

Progesterone steroids from Pfizer CentreOne are available in a range of particle sizes for a broad range of pharmaceutical applications:

  • Progesterone micronized for soft gel
  • Progesterone USP micronized
  • Progesterone USP
  • Progesterone USP wettable powder (Surfactant Free)

Contact us for more information on Pfizer CentreOne progesterone API and related products

Let's collaborate

Chemical name Sort descending CAS# Compendial Formula Molar mass
Progesterone micronized for soft gel Cas # - 57-83-0 Compendial - US, EP, Canada, IP and more
Formula -  


Molar mass - 314.4 g/mol
Progesterone USP Cas # - 57-83-0 Compendial - US, EP, Canada, IP and more
Formula -  


Molar mass - 314.4 g/mol
Progesterone USP micronized Cas # - 57-83-0 Compendial - US, EP, Canada, IP and more
Formula -  


Molar mass - 314.4 g/mol
Progesterone wettable powder Cas # - 57-83-0 Compendial - USP, EP, Canada, IP, JP and more
Formula -  


Molar mass - 314.4 g/mol

Why partner with Pfizer CentreOne for API supply? 

Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.

We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.

Our track record is our strongest asset, and this means our customers can count on us for their critical API supply. 

When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:

  • Reliable API supply at flexible commercial volumes
  • Industry-leading EHS and compliance track record
  • Advanced, efficient and environmentally friendly chemistries and processes
  • Regulatory support to enable your product’s success  
  • Robust, low-risk internal supply chain from raw material to API
  • Transparent timelines and a responsive, dedicated customer support team
  • Drug product development and manufacturing services
  • Experienced teams backed by world-class Pfizer quality manufacturing systems – 25% of Kalamazoo colleagues are in dedicated quality roles 
  • A track record you can trust 

Related API products 

Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.

Enviero Progesterone*
Steroid Intermediate

*Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.

Let’s collaborate on your API today

To find out more about Pfizer CentreOne’s API and intermediates, as well commercial pricing and supply availability click here.