First discovered in 1929 and approved in the 1930s via animal extracts, an economic and more efficient synthesis of progesterone from yams was commercialized in 1940. Subsequently, Pfizer’s legacy company Upjohn, revolutionized the manufacture using a derivative from abundant plant sterols, making Progesterone more broadly available. Progesterone is one of the most prescribed medications in the U.S., with more than 3 million prescriptions written in 20181.
Progesterone steroids from Pfizer CentreOne are available in a range of particle sizes for a broad range of pharmaceutical applications:
Chemical name Sort descending | CAS# | Compendial | Formula | Molar mass |
---|---|---|---|---|
Progesterone micronized for soft gel | Cas # - 57-83-0 | Compendial - US, EP, Canada, IP and more |
Formula -
C21H30O3 |
Molar mass - 314.4 g/mol |
Progesterone USP | Cas # - 57-83-0 | Compendial - US, EP, Canada, IP and more |
Formula -
C21H30O3 |
Molar mass - 314.4 g/mol |
Progesterone USP micronized | Cas # - 57-83-0 | Compendial - US, EP, Canada, IP and more |
Formula -
C21H30O3 |
Molar mass - 314.4 g/mol |
Progesterone wettable powder | Cas # - 57-83-0 | Compendial - USP, EP, Canada, IP, JP and more |
Formula -
C21H30O3 |
Molar mass - 314.4 g/mol |
Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.
We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.
Our track record is our strongest asset, and this means our customers can count on us for their critical API supply.
When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:
Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.
Dexamethasone
Enviero Progesterone*
Heparin
Hydrocortisone
Prostaglandins
Steroid Intermediate
Testosterone
*Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.
To find out more about Pfizer CentreOne’s API and intermediates, as well commercial pricing and supply availability click here.