First synthesized in 1957 and approved for medical use in 1961, dexamethasone is on the World Health Organization's List of Essential Medicines. Available as a generic, dexamethasone is one of the most prescribed medications in the U.S., with nearly 1.5 million prescriptions written by physicians in 20181.

1https://clincalc.com/DrugStats/Drugs/Dexamethasone

A range of chemistries and particle sizes

Dexamethasone from Pfizer CentreOne is available in the following chemistries and particle sizes for a broad range of pharmaceutical applications: 

  • Dexamethasone acetate anhydrous micronized 
  • Dexamethasone sodium phosphate 
  • Dexamethasone USP micronized

For full information on Pfizer CentreOne dexamethasone APIs and related products

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Specifications

Chemical name CAS# Compendial Formula Molar mass
Dexamethasone acetate anhydrous micronized Cas # - 1177-87-3 Compendial - USP, Canada, UK, France and more
Formula -  

C24H33FO7

 Molar mass - 452.5 g/mol
Dexamethasone sodium phosphate Cas # - 2392-39-4 Compendial - US, Canada, EP, Singapore
Formula -  

C22H28FNa2O8P

 Molar mass - 516.4 g/mol
Dexamethasone USP micronized Cas # - 50-02-2 Compendial - USP, EP, JP, Canada and more
Formula -  

C22H29FO5

 Molar mass - 392.4 g/mol

Why partner with Pfizer CentreOne for API supply? 

Pfizer CentreOne’s Kalamazoo, Michigan plant has been Pfizer’s center of hormone and steroid manufacturing excellence for decades. In fact, our team produces approximately 1 million kg of API every year at this cGMP certified and fully accredited API manufacturing facility.

We understand the importance of reliable API supply – unpredictable supply is not an option for essential medicine. Our partnerships with customers are based on trust and transparency and we provide strength through our experience.

    Our track record is our strongest asset, and this means our customers can count on us for their critical API supply. 

    When you choose to partner with Pfizer CentreOne, you are purchasing more than API, you are investing in your product’s future. Our team delivers:

    • Reliable API supply at flexible commercial volumes
    • Industry-leading EHS and compliance track record
    • Advanced, efficient and environmentally friendly chemistries and processes
    • Regulatory support to enable your product’s success  
    • Robust, low-risk internal supply chain from raw material to API
    • Transparent timelines and a responsive, dedicated customer support team
    • Drug product development and manufacturing services
    • Experienced teams backed by world-class Pfizer quality manufacturing systems – 25% of Kalamazoo colleagues are in dedicated quality roles 
    • A track record you can trust 

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    Pfizer CentreOne offers a comprehensive range of API compounds and intermediates for drug product developers and manufacturers.

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    *Enviero progesterone, the first compound to be launched from Pfizer CentreOne’s green-chemistry program, features no metal catalysts and offers a 70% reduction in carbon footprint versus our traditional processes.