The largest manufacturing site in the Pfizer network is in Kalamazoo, Michigan, with facilities spanning a total area of 90 acres. The site has a long legacy of innovation, industrial safety, and regulatory compliance, as well as an industry leading sustainability program, and produces approximately 1 million kg of API and 10 million kg of intermediates every year. The American Chemical Society designated this facility a National Chemical Historic Landmark in recognition of its impact on steroid medicines.