Shape your development masterpiece

At Pfizer CenterOne, we’re backed by the resources and capabilities of Pfizer, a global leader in innovative small molecule API manufacturing. We have navigated the introduction of 400+ fermentation and chemical synthesis steps and processes.

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Your trusted CDMO partner of choice

When it comes to high-quality small molecule manufacturing, we always deliver on what we promise. Our commercial manufacturing capabilities span Pfizer’s global small molecule portfolio, and we’ve packaged this up into services that work for you.

We serve your small molecule API needs from our Kalamazoo, Michigan facility, bringing decades of experience and manufacturing more than 1 million kg of APIs every year. Located in the heart of the United States, the site produces APIs and intermediates using Pfizer quality standards – the same that Pfizer uses for its own branded medicines.

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Pilot cGMP manufacturing

With the flexibility to support small clinical or commercial batches, as well as scaling to commercial volumes, our cGMP pilot facilities can grow with your API demand. This means we are dedicated to your long-term success.

Our team of analytical chemists and engineers are experts at developing and trouble-shooting analytical methods and scaling your process successfully. We collaborate with you to redesign and optimize chemical processes wherever possible. Analytical, engineering and chemistry teams aim to reduce risk so we can confidently scale to fit your unique manufacturing needs.

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Compound types

  • Most small molecules excluding cytotoxics and betalactams
  • From 100 grams to 3+ metric tons


  • Organic synthesis
  • Fermentation and bioprocessing up to 150,000-liter scale
  • Particle sizing
  • Process optimization and scale-up from lab to commercial
  • Containment and segregation
    • Highly potent, steroids, hormones and prostaglandins
    • Controlled substance CII, CIII
    • OEL <1 µg/m³ and 1-10 µg/m³