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Container Closure Systems

You’ve created a superior drug. Now let us help you find the best way to deliver it.

When you’re planning the fill and finish of a sterile injectable, your choice of container closure system matters, scientifically and commercially. On the technical end, any number of interactions between drug and container and/or components and/or silicone can threaten the medication’s purity and stability, such as glass delamination. Other factors can affect dosing and product safety, such as glass breakage or glide- and break-loose forces.

Commercially, to be successful, your container closure system must meet the needs of patients, your target market(s) and your business strategy. Are you racing to launch a novel drug intended for use in hospitals? A vial might be best. A prefilled syringe takes longer to develop but may provide a market advantage if the drug is intended for self-injection.

You can’t afford missteps with timelines looming. We’ve worked with more than one hundred different compounds and numerous container closure systems, and have practical knowledge of markets around the globe. We’re ready to make that knowledge work for you—not just at launch, but for the full lifecycle of your drug.

We offer not just experience but a broad range of options. Your Pfizer CentreOne team stands ready with one of the largest selections of container closure systems in the CDMO industry including:

Closure system Size
Vials, aseptically filled or terminally sterilized 2 – 100 mL
Ampoules, aseptically filled or terminally sterilized 1 – 5 mL
Prefilled syringes (glass) 1 – 3 mL
Cartridges 2 – 5 mL
Onco-Tain™ vials: Proprietary, shatter-resistant vials for hazardous drugs 2 – 100 mL
iSecure™ prefilled syringes: Proprietary syringes that help maintain product integrity, help prevent drug diversion through multiple levels of tamper evidence and are compatible with IV and intramuscular injection sets 1 and 2.5 mL
Delivery systems specifically designed for hospital and ambulatory drug administration

What’s more, once you’ve determined your primary container, we can help with packaging design and multi-lingual secondary packaging and labeling, as well as serialization requirements around the world.